毛志强 教授

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来源:beat365亚洲体育在线

发布日期:2022年12月29日 12:32

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一、基本信息

毛志强,教授,博士生导师,楚天学

研究领域:荧光探针与活体成像、重大疾病的分子诊疗

电子邮件:maozq@hubu.edu.cn

教育背景及工作经历

2012.9—2017.6 武汉大学,博士,分析化学

2017.7—2018.1 中南民族大学,研究助理

2018.2—2019.6 beat365官方网站 化学化工学院,讲师

2019.7-2024.9 beat365官方网站 化学化工学院beat365亚洲体育在线,副教授

2022.3—2023.3 韩国高丽大学(Korea University) 化学系,访问学者

2024.10—至今 beat365官方网站 beat365亚洲体育在线,教授

三、研究方向

目前主要研究方向包括近红外分子荧光探针的研制及活体成像分析、基于智能分子平台的肿瘤诊疗一体化研究等,涉及分子影像脑疾病的早期诊断肿瘤联合治疗等领域,主持国家自然科学基金项目2项、湖北省自然科学基金项目1项,以第一作者/通讯作者在Angew. Chem. Int. Ed. (2篇), Matter (1篇), Adv. Funct. Mater. (1篇, Advanced Science (1篇, Coordination Chemistry Reviews (2), Analytical Chemistry (5), Chemical Science (3篇), J. Hazard. Mater. (1)等国际学术刊物发表SCI论文40余篇;长期应邀担任Chemical Science, Analytical Chemistry, Sensors and Actuators B Chemical等期刊论文审稿人。

四、科研项目

1. 国家自然科学基金面上项目,项目批准号:22174034,2022-01至2025-12,78万元,主持,在研。

2. 国家自然科学基金青年项目,项目批准号:21804033,2019-01至2021-12,31.1万元,主持,结题。

3. 湖北省自然科学基金面上项目,项目批准号:2021CFB305,2021-10至2023-09,8.0万元,主持,结题。

五、代表论文

1. Jiankang Gong, Xiaoyu Wang, Jiao Wu, Changyu Yoon, Yujin Kim, Jingwen Zou, Zhiqiang Mao,* Jong Seung Kim,* Diaminonaphthalene Boronic Acid (DANBA): New Approach for Peroxynitrite Sensing Site. Angew. Chem. Int. Ed. 2024, 63, e202409295. (SCI一区,IF=16.1)

2. Pengzhang Wang, Le Yu, Jiankang Gong, Jianhua Xiong, Soyu Zi, Hua Xie, Fan Zhang, Zhiqiang Mao,* Zhihong Liu,* Jong Seung Kim.* An Activity-Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO-) in the Alzheimer's Disease Brain. Angew. Chem. Int. Ed. 2022, 61, e202206894.  (SCI一区,IF=16.823)

3. Jianhua Xiong, Pengzhan Wang, Subin Son, Zhong Cheng, Fan Zhang, Zhiqiang Mao,* Zhihong Liu,* Jong Seung Kim.* Engineering a theranostic platform for synergistic hypoxia-responsive photodynamic therapy and chemotherapy. Matter 2022, 5, 1502-1519.  (SCI一区, IF=19.967)

4. Zhiqiang Mao, Hyeonji Rha, Jungryun Kim, Xinru You, Fan Zhang,* Wei Tao,* Jong Seung Kim.* THQ–Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores. Advanced Science, 2023, 10, 2301177.  (SCI一区, IF=17.521)

5. Jianhua Xiong, Xiaoyu Wang, Jaewon Kim, Jiankang Gong, Zhiqiang Mao,* Jong Seung Kim,* Zhihong Liu.* Tumor-Activated Prodrug with Synergistic Anti-Stemness Chemical and Photodynamic Therapies. Advanced Functional Materials, 2024, 34,2312590. (SCI一区,IF=19.0)

6. Jianhua Xiong, Weijie Chi, Miantai Ye, Li Zhang, Xiaoyu Wang, Zhiqiang Mao,* and Zhihong Liu.* Activatable Phototherapeutic Prodrug Conquering Hypoxia Limitation to Enhance Chemical Drug Delivery Efficiency. ACS Materials Letters 2024, 6, 2548−2558. (SCI一区, IF=11.4)

7. Zhiqiang Mao, Jianhua Xiong, Pengzhan Wang, Jusung An, Fan Zhang, Zhihong Liu,* Jong Seung Kim.* Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes. Coordination Chemistry Reviews 2022, 454, 214356.  (SCI一区,IF=24.833)

8. Zhiqiang Mao, Ji Hyeon Kim, Jieun Lee, Hao Xiong, Fan Zhang,* Jong Seung Kim.* Engineering of BODIPY-based theranostics for cancer therapy, Coordination Chemistry Reviews 2023, 476, 214908.  (SCI一区,IF=24.833)

9. Xiaoyu Wang, Jiankang Gong, Jiaxuan Wang, Fan Zhang, Zhiqiang Mao*, Zhihong Liu*. Engineering molecular theranostic probes for antibaterial therapy. Trends in Analytical Chemistry, 2023, 167, 117232.  (SCI一区, IF=13.1)

10. Maintai Ye, Yunhui Xiang, Jiankang Gong, Xiaoyu Wang, Zhiqiang Mao,* Zhihong Liu.* Monitoring Hg2+ and MeHg+ Poisoning in Living Body with An Activatable Near-infrared II Fluorescence Probe, Journal of Hazardous Materials, 2023, 445, 130612.  (SCI一区,IF=14.224)

11. Songjiao Li, Peipei Wang, Miantai Ye, Ke Yang, Dan Cheng, Zhiqiang Mao*, Longwei He*, and Zhihong Liu. Cysteine-Activatable Near-Infrared Fluorescent Probe for Dual-Channel Tracking Lipid Droplets and Mitochondria in Epilepsy. Analytical Chemistry, 2023, 95, 5133–5141. (SCI一区,IF=8.008)

12. Pengzhan Wang, Xianhua Cheng, Jianhua Xiong, Zhiqiang Mao,* Zhihong Liu.* Revealing Formaldehyde Fluxes in Alzheimer's Disease Brain by an Activity-Based Fluorescence Probe. Chinese Journal of Chemistry 2022, 40, 1457-1463. (SCI二区, IF=5.560)

13. Zhao Wang, Weiwei Wang, Pengzhan Wang, Zhiqiang Mao,* Zhihong Liu.* Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress. Analytical Chemistry 2021, 93, 3035-3041. (SCI一区,IF=6.986)  

14. Pengzhan Wang, Huocheng Yang, Chang Liu, Mingqiang Qiu,* Xin Ma, Zhiqiang Mao,* Yao Sun,* Zhihong Liu. Recent advances in the development of activatable multifunctional probes for in vivo imaging of caspase-3. Chinese Chemical Letters 2021, 32, 168-178.  (SCI二区,IF= 6.779)

15. Weiwei Wang, Jianhua Xiong, Xinjian Song, Zhao Wang, Fan Zhang, Zhiqiang Mao.* Activatable Two-Photon Near-Infrared Fluorescent Probe Tailored toward Peroxynitrite In Vivo Imaging in Tumors. Analytical Chemistry 2020, 92, 13305-13312.   (SCI一区,IF=6.785)

16. Jianhua Xiong, Weiwei Wang, Caixia Wang, Cheng Zhong, Renqiang Ruan, Zhiqiang Mao*, Zhihong Liu.* Visualizing Peroxynitrite in Microvessels of the Brain with Stroke Using an Engineered Highly Specific Fluorescent Probe. ACS Sensors 2020, 5, 3237-3245.  (SCI一区,IF=7.333)  

17. Yan Lou, Caixia Wang, Siyu Chi, Songjiao Li, Zhiqiang Mao* and Zhihong Liu.* Construction of a two-photon fluorescent probe for ratiometric imaging of hypochlorous acid in alcohol-induced liver injury. Chemical Communications 2019, 55, 12912-12915.  (SCI一区,IF=6.164)

18. Zhiqiang Mao, Miantai Ye, Wei Hu, Xiaoxue Ye, Yanying Wang, Huijuan Zhang, Chunya Li* and Zhihong Liu.* Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues. Chemical Science 2018, 9, 6035-6040.  (SCI一区,IF=9.556)

19. Zhiqiang Mao, Hong Jiang, Xinjian Song, Wei Hu and Zhihong Liu.* Development of a Silicon-Rhodamine Based Near-Infrared Emissive Two-Photon Fluorescent Probe for Nitric Oxide. Analytical Chemistry 2017, 89, 9620-9624. (SCI一区,IF=6.042)

20. Zhiqiang Mao, Hong Jiang, Zhen Li, Cheng Zhong, Wei Zhang and Zhihong Liu.* An N-nitrosation reactivity-based two-photon fluorescent probe for the specific in situ detection of nitric oxide. Chemical Science 2017, 8, 4533-4538.   (SCI一区,IF=9.063)  

21. Zhiqiang Mao, Wenqi Feng, Zhen Li, Lingyu Zeng, Weijie Lv and Zhihong Liu*. NIR in, far-red out: developing a two-photon fluorescent probe for tracking nitric oxide in deep tissue. Chemical Science 2016, 7, 5230-5235.    (SCI一区,IF=8.668)

22. Zhiqiang Mao, Liang Hu, ChengZhong, Heng Zhang, Bi-Feng Liu* and Zhihong Liu*. A dual-mechanism strategy to design a wide-range pH probe with multicolor fluorescence. Sensor. Actuat. B-Chem. 2015, 219, 179-184. (SCI一区,IF=4.758)

Zhiqiang Mao, Liang Hu, Xiaohu Dong, Cheng Zhong, Bi-Feng Liu and Zhihong Liu*. Highly Sensitive Quinoline-Based Two-Photon Fluorescent Probe for Monitoring Intracellular Free Zinc Ions. Analytical Chemistry 2014, 86, 6548-6554.   (SCI一区,IF=5.825)